Neuro-protection of early and short-time applying atorvastatin in the acute phase of cerebral ischem

• 作 者: LiliCui;XiangjianZhang;RuiYang;LinaWang;LinglingLiu;MinLi;WeiDu;
• 机 构: Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang , Hebei 050000, C
• 出 处: 中华医学会神经病学分会第九届全国脑血管病学术会议
• 发表日期: 2010年期

　　Background: It has been proved that chronic administration and pre-treatment withatorvastatin could protect brain tissue against ischemic injury.However, little is known regarding the effect of atorvastatin in the acute phase of ischemic stroke.This study investigated the potential neuro-protective effects of atorvastatin and underlying mechanisms in vivo.Methods: Male Sprague-Dawley rats were subjected to permanent middle cerebral artery occlusion (MCAO).