【摘 要】
：
Coumarins represent a class of synthetically useful heterocyclic compounds that have been accredited with a broad range of biological/pharmacological action such as antimicrobial,antifungal,antiviral,
【机 构】
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College of Pharmacy and Institute of Medicinal Chemistry,Hubei University of Medicine,Shiyan 442000,
【出 处】
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中国化学会第十六届全国有机合成化学学术研讨会
论文部分内容阅读
Coumarins represent a class of synthetically useful heterocyclic compounds that have been accredited with a broad range of biological/pharmacological action such as antimicrobial,antifungal,antiviral,anticoagulant,antitumor,and anti-inflammatory activities.Moreover,coumarin derivatives have the superior thermal stability and outstanding optical properties,including extended spectral responses,high quantum yields,and superior photostability.[1] On the other hand,heterocycles containing the oxazole nucleus also exhibit various biological and optical activities.[2] The introduction of a oxazole ring to the coumarin system is expected to influence the biological/optical activities significantly.Recently,we have been interested in the synthesis of fused pyrimidinones and imidazolones via aza-Wittig reaction,with the aim of evaluating their biological activities.[3,4]In our work,based on the structure of coumarin where there exists delocalization of π-electrons,a series of coumarin derivatives containing oxazole ring moiety were effectively synthesized by synthetic strategy of aza-Wittig reactions of functionalized iminophosphoranes(Fig.1).Furthermore,their structures are confirmed by by NMR,EI-MS,IR and elementary analysis.In addition,the optical properties including UV-vis/Fluorescence behavior performance are in progress.
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