Discovery of hPH20 and hSPACA1 immunocontraceptive epitopes and their effects on fertility in male a

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：klyx808

【摘要】

：

Current research concerning human antisperm contraceptive vaccines is focused on delineating infertility-related epitopes to avoid autoimmune disease.We constructed phage-display peptide libraries to

【作者】

：

Xuemei Chen Xiaodong Liu Xiuhua Ren Xuewu Li Li Wang Weidong Zang

【机构】

：

Department of human anatomy, Basic medical college of Zhengzhou University, Zhengzhou 450001, Henan,

【出处】

：

The 18th Congress of the International Federation of Associa

【发表日期】

：

2014年8期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Current research concerning human antisperm contraceptive vaccines is focused on delineating infertility-related epitopes to avoid autoimmune disease.We constructed phage-display peptide libraries to select epitope peptides derived from hPH20 and hSPACA1 using sera collected from infertile women harboring antisperm antibodies.Following five rounds of selection,positive colonies were reconfirmed for reactivity with the immunoinfertile sera.

其他文献

Horizons in development

Our discovery of rivet-like structures in the amnion that pin together key tissue layers is cause for optimism amongst medical scientists exploring causes of premature births following preterm rupture

会议

The potential roles of Slit/Robo1 signaling on neural tube formation and neural crest cells migratio

Neural tube is the primary rudiment responsible for the development of the central nervous system, while neural crest cells are derived from the edges of developing dorsal neural tube.It is well-known

会议

Gene and environment interactions during early cortical development and consequences for long-term n

Cortical development is a complex amalgamation of proliferation, migration, differentiation, and circuit formation.These processes follow defined timescales and are controlled by a combination of intr

会议

PDGFRα expression in the different brain regions of the rat at different postnatal time

To study expression of platelet-derived growth factor receptor α (PDGFRα) in the different brain regions of the rat at different postnatal time.Extracting mRNA and protein from cerebral cortex, hippoc

会议

Immunocytochemical peculiarities of the human foetal pituitary cells

We present here our results about the peculiar immunoreactivity (ir) of pituitary cells, concerning colocalisation of hypophysial hormones in the human foetus aged 16-22 weeks: growth hormone (GH) or

会议

The expression of insulin-like growth factor-I and its receptor during development of rat embryo bra

To study temporal expressions of Insulin-like growth factor-Ⅰ (IGF-Ⅰ) and IGF receptor1 (IGF-1R) in the developing brain of rat and explore their functions in nervous system development.

会议

Expression of microtubule-associated protein 2 (MAP-2) and nestin in the developing digestive tract

To explore the role of MAP-2 and nestin in human embryonic digestive tract of developmental stages.Immunohistochemistry and in situ hybridization were used to detect the expressions of MAP-2 and nesti

会议

GRTH regulated noncanonical signaling pathways sustains adult spermatogenesis in mice

Non-obstructive azoospermia (NOA) is one of the major disorders which cause male infertility, but the mechanism of this disease is largely unknown.In the present study, three missense mutations of GRT

会议

Competing endogenous lincRNA-RoR plays a critical role in the network of microRNAs and core transcri

Embryonic stem cells (ESCs) have an unlimited potential to be propagated in culture in an undifferentiated state (self-renewal).The transcriptional and epigenetic networks controling ESC self-renewal

会议

Expression change of Hes1 in the neuroepithelial cells of neural tube defects induced by hyperthermi

Neural tube defects (NTDs) are common congenital malformations that result in infant mortality or severe disability.Hairy and enhancer of split homolog-1(Hesl) has an important role in regulating cell

会议

Discovery of hPH20 and hSPACA1 immunocontraceptive epitopes and their effects on fertility in male a

其他学术论文