【摘 要】
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Background: Hand, foot, and mouth disease (HFMD) is a worldwide childhood illness.The number of reported cases has significantly increased in mainland China in recent years.County-level HFMD informati
【机 构】
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School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Municipal Key La
【出 处】
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首都医科大学公共卫生学院第四届研究生学术论坛
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Background: Hand, foot, and mouth disease (HFMD) is a worldwide childhood illness.The number of reported cases has significantly increased in mainland China in recent years.County-level HFMD information across the entire country for long periods has rarely been reported.This article characterized spatial patterns and identified space-time clusters of HFMD at the county level.Methods: Data of reported HFMD cases for each county from 1 January 2008 to31 December 2012 were obtained from the Chinese Center for Disease Control and Prevention.Cluster analysis, spatial autocorrelation, and retrospective scan methods were used to explore the diseases spatial-temporal distributional patterns.Results: Annual reported incidences varied greatly among counties, ranging from 0 to 74.31‰ (median [interquartile range]: 5.42‰[1.54‰-13.55‰]).Counties near provincial capital cities typically had higher incidences than more rural counties.Seasonal distribution between northern and southern regions was distinct by cluster analysis: two peaks were found in southern China and one peak in northern China.Significant clustering patterns were detected using global spatial autocorrelation (P<0.001).HFMD hotspots were found mainly distributed in coastal provinces by using Anselin Local Morans I,although they changed from year to year.Using retrospective scan analysis, spatial-temporal clusters were mainly located in eastern and southern Chinese cities, as well as provincial capitals and nearby areas.Conclusions: Spatial, temporal aggregations and spatial-temporal clusters of HFMD were found at the county level in mainland China.More attention should be focused on eastern and southern counties, especially those close to provincial capitals.
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