【摘 要】
：
Perinatal brain injury including white matter damage (WMD) is highly related to sensory, motor or cognitive impairments in humans born prematurely or who develop later cerebral palsy (CP).Our aim was
【机 构】
：
Aix-Marseille Université France
【出 处】
：
BIT`s 3rd Annual World Congress of NeuroTalk-2012(2012第三届国际神
论文部分内容阅读
Perinatal brain injury including white matter damage (WMD) is highly related to sensory, motor or cognitive impairments in humans born prematurely or who develop later cerebral palsy (CP).Our aim was to examine the neuroanatomical, functional and behavioral changes in adult rats that experienced prenatal ischemia (PI), thereby inducing WMD.PI was induced by unilateral uterine artery ligation at El7 in pregnant rats.We assessed performances in gait, cognitive abilities and topographical organization of maps, and neuronal and glial density in primary motor and somatosensory cortices, the hippocampal complex and prefrontal/cingulate cortex, as well as axonal degeneration and astrogliosis.We found WMD/axonal degeneration in the corpus callosum, brainstem, hippocampal complex, frontal and somatosensory cortices, but not in the motor cortex after PI.Astrogliosis was detected in almost all these areas, except in the frontal areas.PI rats exhibited mild locomotor impairments associated with musculoskeletal histopathology including signs of spasticity.Motor map organization and neuronal density were normal in PI rats, contrasting with major somatosensory map disorganization, reduced neuronal density, and a marked reduction of inhibitory interneurons, as well as imbalance of excitatory/inhibitory neurotransmission.PI rats also exhibited spontaneous hyperactivity in open-field test and short and long-term deficits in object recognition memory tasks associated with abnormal neuronal density, axonal degeneration and astrogliosis in related brain areas, while spatial navigation in the classic watermaze and neuronal density within the hippocampus were preserved.Thus, our rodent model of WMD recapitulates the main deficits observed in children that were born preterm or later develop catastrophic diseases, such as ADHD or CP and may offer new opportunities to explore neuroprotective strategies to prevent or limit immature brain damage.
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