SALVIANOLIC ACID A INIBITS SMOOTH MUSCLE CELL PROLIFERATION THOUGH CREB-MEDIATED P21 INDUCTION AND P

来源 :19th Annual Scientific Meeting of the Institute of Cardiovas | 被引量 : 0次 | 上传用户：wiaini0

【摘要】

：

【作者】

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L Sun R Zhao L Zhang WK Zhang SQ Yang GR He JK Song W Zhang GH Du

【机构】

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Chinese Academy of Medical Science and Peking Union Medical College;Beijing Key Laboratory of Drug T

【出处】

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19th Annual Scientific Meeting of the Institute of Cardiovas

【发表日期】

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2015年9期

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Objectives: Cyclic adenosine monophosphate (cAMP)/proteinkinase A (PKA)/cAMP response element (CRE) binding protein (CREB) signaling cascade negatively regulates platelet derived growth factor-BB (PDGF-BB) induced smooth muscle cell (SMC) proliferation, which is a critical event in the initiation and development of restenosis and atherosclerotic lesions.Salvianolic acid A (SAA) is one of the most abundant polyphenols extracted from salvia.The aim of this study is to investigate whether SAA exerts an action on PDGF-BB-induced proliferation via cAMP/PKA/CREB mochanism.

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SALVIANOLIC ACID A INIBITS SMOOTH MUSCLE CELL PROLIFERATION THOUGH CREB-MEDIATED P21 INDUCTION AND P

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