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Objective Most of cancer cells rely on aerobic glycolysis,which is now considered as one hallmark of cancer,to generate the energy needed for cellular processes(e.g.proliferation).Nur77,as one of the orphan nuclear receptors,plays diverse and pivotal roles in metabolism and cancer,however its function in prostate cancer remain elusive.In the present study,we aimed to explore the effect and molecular mechanism of nur77 on prostate cancer.