【摘 要】
：
The tumor suppressor p53 lies at the hub of cellular signaling networks that are activated by various stress signals.As a nuclear transcription factor,p53 c
【机 构】
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NanjingUniversity,China
【出 处】
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The XXIX International Colloquium on Group-Theoretical Metho
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The tumor suppressor p53 lies at the hub of cellular signaling networks that are activated by various stress signals.As a nuclear transcription factor,p53 can regulate expression of a large number of target genes.The levels,subcellular localization,posttranslational modifications,and cofactors of p53 all mediate its function and dynamics.We have proposed integrated models of the p53 network and explored how the p53 pathway responds to DNA damage and energy stress by numerical simulations.We found that p53 can induce distinct cellular outcomes including cell cycle arrest,senescence,and apoptosis.We characterized the dynamics of the p53 network in detail and revealed the underlying molecular mechanisms for the cellular responses to stresses.
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