The anti-tumor mechanism of a novel Shp2 protein tyrosine phosphatase inhibitor from entomogenous fu

来源 :中国化学会第十届全国天然有机化学学术会议 | 被引量 : 0次 | 上传用户：Mr_Sunfox

【摘要】

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【作者】

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Meng-Meng Cao Cui-Cui Wang Fan Liang Chuan Chen Du-Qiang Luo

【机构】

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Hebei University, College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagn

【出处】

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中国化学会第十届全国天然有机化学学术会议

【发表日期】

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2014年11期

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A novel SHP2 inhibitor-fumosorinone (Fumos) from entomogenous fungi was discovered;it possesses the selective inhibition for Shp2 over other PTPs (PTP1B, TCPTP, Shpl, HePTP, Lyp,STEP, PTPH1, PTPRA, Cdc25b, and MEG2).Fumos also showed potent antitumor activity against a broad spectrum of human cancer cell lines, and inhibited epidermal growth factor (EGF)-induced Shp2-dependent activation of Ras/Erk signal pathway and the dephosphorylation of paxillin, but did not block EGF-induced Gabl-Shp2 association.

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The anti-tumor mechanism of a novel Shp2 protein tyrosine phosphatase inhibitor from entomogenous fu

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