【摘 要】
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As an extreme form of abnormally synchronized activity,epilepsy may modify patterns of organization in the nervous system.It is clear that enhanced glutamat
【机 构】
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Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
As an extreme form of abnormally synchronized activity,epilepsy may modify patterns of organization in the nervous system.It is clear that enhanced glutamatergic excitatory synaptic transmission with alterations in the expression of ionotropic glutamate receptors is a mechanism critical for seizure susceptibility and excitotoxicity.However,the exact quomodo and the roles of regulated N-methyl-D-aspartate receptor (NMDAR) composition and expression of a major postsynaptic density (PSD) scaffolding molecule,PSD-95,are as yet unclear.To study protein expression changes after epileptiform discharges in cultured immature rat cortical neurons,we divided cells into three groups which were transiently exposed to regular Neurobasal/B27 (Control group),physiological solution (PS group) and magnesium-free physiological solution (MGF group) at cultured day 6.Neurons at three different culture ages (DIV7,DIV12 and DIV 17) were collected for immunoblotting analysis.
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