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Intraparticle diffusion of fractionated Saudi vacuum residue was evaluated in four NiMo/Al2O3-SiO2 catalysts with well-defined and uniform pore structures under HDS reaction conditions in a trickle-bed reactor.The well-defined and uniform pore structure catalysts were preparred by loading MoCo active components into the SiO2 opal materials which were prepared by ordered packing the monodisperse colloidal SiO2 microspheres.