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目的 Aberrant activation of β-catenin signaling by both WNT-dependent and-independent pathways has been demonstrated in asthmatic airways,which is thought to contribute critically in remodeling of the airways.Yet the exact role of β-catenin in asthma is very poorly defined.As weve previously reported abnormal expression of β-catenin in a toluene diisocyanate (TDI)-induced asthma model,in this study we evaluated the therapeutic efficacy of two small molecules XAV-939 and ICG-001 in TDI-asthmatic male BALB/c mice,which selectively block β-catenin mediated transcription.