【摘 要】
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Cells sense and adapt to changes in the environment through the initiation and execution of necessary and specific processes.Autophagy is such a process conserved by eukaryotic cells to face poor cond
【机 构】
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Zhejiang University School of Medicine
【出 处】
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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
论文部分内容阅读
Cells sense and adapt to changes in the environment through the initiation and execution of necessary and specific processes.Autophagy is such a process conserved by eukaryotic cells to face poor conditions such as nutrient deficiency, although its original function is defined as the lysosomal digestion of intracellular protein aggregates and damaged organelles.Despite the identification of numerous autophagy-related genes (Atgs), most of them contribute to the formation of autophagosomes, the signaling events for the initiation of autophagy remain indefinite.In addition to the verification of several protein complexes for phagophore generation and vesicle nucleation on membranes, and the ubiquitin-like conjugation systems required for certain Atg proteins to execute their functions, emerging evidence have suggested that the acetylation-deacetylation of a number of Atg proteins is essential for their activities in autophagy.However, exactly what occurs mechanistically to enable these Atg proteins to be activated by acetylation-deacetylation thereafter initiating autophagy, and how the activities of specific acetyltransferase and/or deacetylase are regulated, are largely unclear.I will present our resent results that cover the molecular mechanisms by which autophagy is controlled by LC3 (Atg8) deacetylation and the responsible deacetylase Sirt1 is activated, upon starvation.
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