Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-gated Sodium Channels from Bindin

• 作 者: FanglingChen;WenxinHuang;TaoJiang;RileiYu;
• 机 构: Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean U
• 出 处: 第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018)
• 发表日期: 2018年期

　　Voltage-gated sodium(NaV)channels generate and propagate action potentials in excitable cells,and several NaV subtypes have become important targets for pain management.The μ-conotoxins inhibit subtypes of the NaV with varied specificity,but often lack of specificity to interested subtypes.Engineering the selectivity of the μ-conotoxins presents considerable complexity and challenge,as it involves the optimization of their binding affinities to multiple highly conserved NaV subtypes [1-3].