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In mammals,neurogenesis occurs in the subgranular zone (SGZ) of the dentate gyrus (DG) throughout adulthood.The continuous generation of DG neurons has been suggested to be involved in theacquisition of new memories and in the behavioral effects of neuropathy.The formation of the DG is a complex process involving cell proliferation,migration and neuronal differentiation.Factors that regulate early DG development are thought to have similar functions in adult neurogenesis,although the molecular mechanisms underlying neurogenesis in the DG are not fully understood.