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Iron is the most abundant transition metal in biology and an essential cofactor for many cellular enzymes.In human, systemic iron homeostasis is tightly regulated and its perturbation is an initial cause of several disorders, including genetic and sporadic neurodegenerative disorders.An opportunity to investigate the iron involvement in neurodegenerative processes is the group of diseases, referred to as "Neurodegeneration with Brain Iron Accumulation", in which diagnostic imaging and autopsy findings reveal focal iron accumulation in specific regions of the brain.Neuroferritinopathy (NF) belongs to this group of diseases.