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目的 观察含紫杉醇的化疗方案治疗晚期乳腺癌的疗效及不良反应。方法 用含紫杉醇的化疗方案治疗晚期乳腺癌 3 0例 ,紫杉醇剂量 13 5mg/m2 ,均匀 3h静脉输注 ,3～ 4周重复 1次 ,平均每例给 4次。在紫杉醇化疗前常规给予地塞米松、苯海拉明和西米替丁预防过敏反应。结果完全缓解 (CR) 3例 ,占 10 % ,平均缓解期 1 6个月 ,部分缓解 (PR) 10例 ,占 3 3 % ,平均缓解期 5个月 ,总有效率 4 3 % ( 13 / 3 0 )。主要不良反应为白细胞下降、肌肉关节疼痛、手足麻木、脱发和面色潮红。结论 紫杉醇治疗晚期乳腺癌疗效肯定 ,不良反应可耐受。
Objective To observe the efficacy and adverse reactions of paclitaxel-containing chemotherapy in the treatment of advanced breast cancer. Methods Paclitaxel-containing chemotherapy regimens were used to treat advanced breast cancer in 30 patients. The paclitaxel dose was 155 mg/m2, 3 h intravenous infusion was repeated, and 3 to 4 weeks were repeated. The average case was given 4 times. Dexamethasone, diphenhydramine, and cimetidine were routinely given before paclitaxel chemotherapy to prevent allergic reactions. Results Complete remission (CR) 3 cases, accounting for 10%, average remission period of 16 months, partial remission (PR) in 10 cases, accounting for 3%, average remission period of 5 months, total effective rate 4 3% ( 13/ 3 0 ). The main adverse reactions were white blood cell decline, muscle and joint pain, numbness in hands and feet, hair loss and facial flushing. Conclusion The efficacy of paclitaxel in the treatment of advanced breast cancer is affirmative and adverse reactions can be tolerated.