【摘 要】
：
Over the last decade yeast,a single-celled eukaryote,has become a widely used model system to study eukaryotic aging.Two assays have been developed.In the r
【机 构】
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DepartmentofBiochemistry,Box357350,UniversityofWashington,USA
【出 处】
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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
Over the last decade yeast,a single-celled eukaryote,has become a widely used model system to study eukaryotic aging.Two assays have been developed.In the replicative aging assay,the number of times that one cell can divide and produce daughter cells is defimed as its life span.In the chronologic assay,aging is defined as the time a yeast cell can maintain viability in a non-replicative state.While a number of genes have been reported to affect replicative or chronologic aging in yeast,the difficulty of the assays has precluded a complete assessment of the yeast genome.Further,the relationship between the two yeast assays has not been determined.We have performed a genome-wide screen to identify the genes controlling chronological aging,and examined the replicative life spans of over 600 yeast strains each lacking a single gene.These screens have identified a number of new genes that control yeast aging.Current research is aimed at better defining the molecular pathways controlling replicativeaging and the links between calorie restriction and metabolism.Finally,we seek to understand the relationships between aging in yeast and more complex model systems.
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