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Objectives The NIH Stroke Scale (NIHSS) may not appropriately assess the spectrum of young sex-related stroke neurologic deficits.We determined the cutoff baseline NIHSS score that predicts independent daily life activity at discharge in young male vs female ischemic strokes.Methods We conducted this study in 1451 young Chinese adults with acute cerebral ischemic stroke as determined by the modified Rankin Scale (mRS)at discharge.