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Myeloid Deprived Suppressor Cell(MDSC)has been raised to be a novel target for multiple cancers.However,target agents on MDSC has not displayed promising efficacy.One of the critical reasons shall be less optimal patient selection.In the present study,we aimed to identify clinical parameters relevant to MDSC level in hepatocellular carcinoma(HCC)patients for future MDSC targeted therapy.In the present study,a series of 55 HCC patients(testing group)and 20 healthy donors were analyzed investigating frequencies of MDSC in peripheral blood mononuclear cells(PBMC).