【摘 要】
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Objective There are substantial evidences supporting that the interneuron play a critical role in limiting the spread of epileptiform discharges in animal epilepsy model, however the change of interne
【机 构】
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State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sc
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
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Objective There are substantial evidences supporting that the interneuron play a critical role in limiting the spread of epileptiform discharges in animal epilepsy model, however the change of interneuron function in the human epileptic tissue is not clearly elucidated.This study is to explore the intrinsic electrophysiological properties of interneurons in the human epileptic tissue.Methods Epileptic tissues (n =24, patients aged 10-51 years) were obtained from patients who underwent neurological surgery for epileptic seizures.Control tissues (n =8, patients aged 15-52 years) were obtained from glioma or meningioma patients.By using whole cell patch recording, intrinsic electrophysiological properties of interneurons were analyzed in the human epilepsy and control tissues.Results (1) The threshold of action potential of interneurons of epilepsy brains increased compared with control group.(2) Inter-spike intervals (ISI, an index of spike capacity) and the standard deviation of spike timing (SDST, an index of spike precision) of interneurons gradually increased compared with control group.(3) Refractory periods (RP) in the interneuron prolonged compared with control group.(4) The ability of input-output in the part of interneuron decreased with the same gradually increased depolarization currents compared with control group.(5) The frequency and amplitude of spontaneous EPSCs of interneurons decreased compared with control group.Conclusion The functional attenuation of interneuron may play an important role in the process of epileptogenesis in patients.
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