Neural stem/progenitor cells in the postnatal subventricular zone give rise not only to granular and

• 作 者: ZhengangYANG;
• 机 构: Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shan
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Intemeurons in the granule cell layer (GCL) and glomerular layer (GL) of the olfactory bulb (OB) are generated from neural stem/progenitor cells in the subventricular zone (SVZ) of the lateral ventricle.However,little is known about the origin of intemeurons in the external plexiform layer (EPL) of the OB.On the basis of the concept of corticogenesis,we hypothesized that intemeurons in the EPL of the rodent OB also originate in the SVZ.In the present study,replication-incompetent retroviruses encoding the marker gene,human placental alkaline phosphatase (AP),were injected into the lateral ventricles of postnatal day 4 Wistar rats to label dividing cells in the SVZ.Two days after injection,AP labeled cells had migrated into the OB.