Molecular simulations study of Ligand-release mechanism in an odorant-binding protein from the south

• 作 者: HuiYu;XiZhao;Xian-liFeng;Xu-riHuang;
• 机 构: State Key Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry,
• 出 处: 中国化学会第28届学术年会
• 发表日期: 2012年期

　　Pheromone-binding proteins (PBP) transport hydrophobic pheromones through the aqueous medium to their receptors.The odorant binding protein (OBP) of Culex quinquefasciatus (CquiOBP1),which binds to an oviposition pheromone (5R,6S)-6-acetoxy-5-hexadecanolide (MOP),plays a key role in sensing oviposition cues.However,so far the mechanism of MOP-release from the protein is unclear.