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According to the derivation of fracturing fluid filter loss and leak-off depth ,this paper come to a set of simple calculation procedure of skin factors considering fracturing fluid leak-off, this method considers the wall building and non- wall building filtration model simultaneously. Based on the pseudo stable fracturing wells productivity prediction model, the effect of filtration damage of fracture face on fracturing well productivity was studied. Through case history computational analysis, fracturing fluid leak-off more easily bring about productive capacity decline in low permeability layer.