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Purpose: To research the expressions of B7-H3 and B7-H4 proteins and the effect of sorafenib on their expressions in human hepatoma cell lines(HepG2,Hep3B,BEL-7402,BEL-7404,BEL-7405,QGY-7701,QGY-7703,SMMC-7721,MHCC97H,MHCC97L,HCCLM3 and HCCLM6).