Brutions tyrosine kinase(BTK)is a key component of the B-cell receptor signaling pathway which plays a critical role in B-cell development.Ample evidence indicates that the dysregulation of BTK is ass
The design,synthesis,and biological activity evaluation of the potency of new inhibitors of sphingosine kinases 1 and 2(SphK1 and SphK2),the enzyme that catalyzes the phosphorylation of D-erythro-sphi
The overexpressed GSTπ isozyme in tumor cells was regarded as targets for the design of anti-cancer agents.Herein,a group of GSTπ-based nitric oxide(NO)-releasing derivatives of oleanolic acid(OA)(1–9
Lorcaserin was approved in June 2012 by the FDA for the treatment of obesity.1 Several methods for the synthesis of lorcaserin have been reported,but these methods are unsuitable for industrial-scale
Gout is a heterogeneous disease associated with hyperuricemia and is featured by urate crystals deposited in joints and soft tissues.Xanthine oxidase(XO)is a key enzyme involved in the occurrence of g
A series of novel 1-[(1R,2S)-2-fluorocyclopropyl]naphthyridone derivatives 21-24 containing an oxime-functionalized pyrrolidine moeity were designed,synthesized and evaluated for their biological acti
Twenty one of Vandetanib derivatives containing an oxime-functionalized piperidine moiety were designed,synthesized and characterized by1HNMR,13CNMR,MS and HRMS.[1] One of them,IMB-1502 shows good act