天冬氨酸-β-CD衍生物拆分6种药物对映体

来源 :手性中国2014学术研讨会 | 被引量 : 0次 | 上传用户：shaofenglanzi

【摘要】

：

本文合成了一种新的单一异构体离子型环糊精衍生物-天冬氨酸-β-CD衍生物(A-CD).以A-CD为手性选择剂,用毛细管电泳法对特布他林、氯丙那林、丙卡特罗、妥洛特罗、克伦特罗、卡维地洛6种手性药物进行了对映体分离研究.使用磷酸盐缓冲溶液为背景电解质,考察了手性选择剂浓度、背景电解质pH、缓冲盐浓度对分离的影响,优化了对映体分离条件.结果表明,在pH为2.0、浓度为50 mmol·L-1的磷酸盐缓冲

【作者】

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刘永静孙铁民郭兴杰

【机构】

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沈阳药科大学,辽宁省沈阳市沈河区文化路103号,110016;福建中医药大学,福建省福州市闽侯上街邱阳路1号,350122

【出处】

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手性中国2014学术研讨会

【发表日期】

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2014年3期

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天冬氨酸-β-CD衍生物拆分6种药物对映体

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