【摘 要】
：
To develop effective mucosal vaccines,two types of functional liposomes,the mannosylated lipid Aliposomes(MLLs)with a size of around 200 nm and the stealth lipid A-liposomes(SLLs)of 50 nm,both loaded
【机 构】
：
School of Biological and medical Engineering,Hefei University of Technology,Hefei 230009,China
【出 处】
：
2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年
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To develop effective mucosal vaccines,two types of functional liposomes,the mannosylated lipid Aliposomes(MLLs)with a size of around 200 nm and the stealth lipid A-liposomes(SLLs)of 50 nm,both loaded with a model antigen ovalbumin and ammonium bicarbonate(NH4HCO3),were prepared and fabricated together into microneedles to form the proSLL/MLL-constituted microneedle arrays(proSMMAs)which anhydrous and stable and,upon rehydration,dissolved rapidly,recovering the initial MLLs and SLLs.
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