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Human T lymphocytes, bearing T-cell receptor (TCR) γδ, play an important role in tumor immunosurveillance and antitumor immune responses.Functionally, without negative selection during thymus development, γδ T cells are believed to take advantage of their limited diversity to recognize stress-induced self protein antigens which are highly expressed on the tumor cells.The antigen binding site of TCR γδ is primarily formed from three complementary determinant regions (CDR) contributed by each Vγor Vδ domain, while the antigen specificity of TCR γδ depended solely on CDR3δ.