【摘 要】
：
Introduction: Small conductance calcium-activated potassium channel (SK channel) plays an important role in heart.Four subtype of SK channel are classified
【机 构】
：
Key Laboratory of Medical Electrophysiology,Ministy of Education of China,and the Institute of Cardi
【出 处】
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International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Introduction: Small conductance calcium-activated potassium channel (SK channel) plays an important role in heart.Four subtype of SK channel are classified according to their sensitive to apamin.Electrophysiological properties of SK2 channel are voltage-independent and solely activated by changes in intracellular calcium concentration.L-type calcium channel inhibitor verapamil were adopted to observe the regulation of SK2 channel in this paper.Methods: Single human cardiac myocyte was isolated by two-step enzyme digestion.The wholecell patch clamp was used to record the SK2 current.Verapamil (10 μmol/L) and apamin (100 nmol/L) were added into bath solution respectively to observe the change of current.Result: Compared with control group, the apaminsensitive currents density of the verapamil group showed a significant decrease in human atrial myocytes.It indicates that part of SK2 current can be inhibited by verapamil.Conclusion: There may be functionally coupling between SK2 channels and L-type calcium channels in human myocardium cells.
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