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  5. A novel pharmacokinetic model based on the complex elimination of monoclonal antibodies for bevacizu

A novel pharmacokinetic model based on the complex elimination of monoclonal antibodies for bevacizu

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：t123
【摘 要】
：
Much more complex pharmacokinetic (PK) properties including a nonlinear pharmacokinetics and a significant variation in individual PK process were gradually exhibited by monoclonal antibody (mAb) drug
【作 者】
：
Lei Wang Shan Ji Zeneng Cheng 
【机 构】
：
School of Pharmaceutical Sciences, Central South University,Changsha, Hunan 410013, China
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
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Much more complex pharmacokinetic (PK) properties including a nonlinear pharmacokinetics and a significant variation in individual PK process were gradually exhibited by monoclonal antibody (mAb) drugs compared to those typically associated with small-molecule drugs, and the complex PK process of mAb drugs can not be appropriately described by traditional PK models1-3.
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