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The combination of multiple therapy strategy has attracted more attention because their promising antitumor effect.In this study,the doxorubicin (DOX) and indocyanine green (ICG) loaded Gd2O3:Eu3+@P(NIPAm-co-MAA)@THA@cRGD nanocomposites (DOX-ICG-TPNPs@cRGD) have been prepared for multi-mode imaging diagnosis and therapy.