HMGB1 is associated with the pathogenesis of Henoch-Sch(o)nlein purpura

• 作 者: TaoChen[1]Zai-peiGuo[2]ShaQin[2]NaCao[2]Meng-mengLi[2]
• 机 构: Department of Dermatovenereology,West China Hospital of Sichuan University,Chengdu,610041,Sichuan,Ch
• 出 处: 第9届中国皮肤科医师年会
• 发表日期: 2013年期

　　High mobility group box-1 (HMGB1),has been implicated as a pro-inflammatory cytokine in the pathogenesis of various inflammatory and autoimmune diseases.However,information about HMGB1 in Henoch-Sch(o)nlein purpura (HSP) is still unknown.Herein,we investigated the role of HMGB1 in patients with HSP and the pro-inflammatory effects of HMGB1 on human dermal microvascular endothelial cell line (HMEC-1).Serum HMGB1 levels in patients with HSP,together with patients with allergic vasculitis (AV) and urticarial vasculitis (UV) were detected by enzyme-linked immunosorbent assay (ELISA).