Multifunctional pH-sensitive Micelles for Tumor-Specific Uptake and Cellular Delivery

• 作 者: T.H.Yang;F.Li;H.T.Zhang;L.Fan;Y.B.Qiao;G.G.Tan;H.Wu;
• 机 构: Department of Pharmaceutical Analysis,School of Pharmacy,Fourth Military Medical University,Xi'an 7
• 出 处: 中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
• 发表日期: 2014年期

　　The distinct ability of cell-penetrating peptides(CPPs)has lead to development of novel drug delivery methods in human cells for therapeutic purposes.The lack of specific selectivity is a main obstacle of CPPs.A novel delivery method based on acid-sensitive micelles using for the introduction and protection of TAT was developed in this study.Doxorubicin-TAT conjugate(Dox-TAT)was loaded in the luteinizing hormone-releasing hormone modified poly(ethylene glycol)-poly(L-histidine)-doxorubicin(LHRH-PEG-PHIS-Dox)micelle.