Regulation of mitotic spindle behavior and cytokinesis by the tumor suppressor CYLD

来源 :中国遗传学会第九次全国会员代表大会暨学术研讨会 | 被引量 : 0次 | 上传用户：hydhyd112

【摘要】

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【作者】

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Yunfan Yang Jie Ran Jinmin Gao Shaojun Suo Min Liu Dengwen Li Jun Zhou

【机构】

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Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071

【出处】

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中国遗传学会第九次全国会员代表大会暨学术研讨会

【发表日期】

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2013年11期

【关键词】

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CYLD mitotic spindle cytokinesis deubiquitination

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　　The tumor suppressor CYLD contains three cytoskeleton-associated protein glycine-rich (CAP-Gly) domains in the amino terminus and a deubiquitinase domain in the carboxyl terminus.The first two CAP-Gly domains mediate the interaction of CYLD with the microtubule cytoskeleton, whereas the deubiquitinase domain catalyzes the removal of lysine-63-1inked polyubiquitin chains from target proteins, leading to the inhibition of cell survival and proliferation.

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Regulation of mitotic spindle behavior and cytokinesis by the tumor suppressor CYLD

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