Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersome for tumor meta

• 作 者: LinHou;MingKong;
• 机 构: College of Marine Life Science,Ocean University of China,Yushan Road,Qingdao,Shandong 266003,China
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年期

　　Tumor metastasis accounts for 90 %of cancer-associated deaths and is almost inaccessible by chemotherapy,surgical operation or radiotherapy.Before distant spreading,metastasized cancers have invaded the lymphatic system as a first step in their progression [1].Hence,effective control of the disease state of the lymphatics which drain a tumor site is crucial to treatment.Transdermal drug delivery could avoid the first-pass hepatic effect and fluctuation of blood concentration,and greatly facilitate drug accumulation in the lymphatics [2].