Long-termfunctional and quality of life evaluation after treatment of total laryngectomy VS concurre

• 作 者: Xui-rui Zhang Feng Yu Lie-qiang Liao Hong-hong Yan Yi-bo Zhou Xue-kui Liu
• 机 构: Department of Otorhinolaryngology, Guangzhou Ear Nose Throat Neck Surgery Hospital, Guangzhou, Guang
• 出 处: 2016年广州市医学会耳鼻咽喉科学分会学术年会
• 发表日期: 2016年8期

　　To estimate long-term quality of life (QOL) of patients with stage Ⅲ laryngeal carcinomas treated by total laryngectomy(TL) or concurrent chemoradiotherapy (CRT).Methods: From 2003 to 2011,233 patients with stage Ⅲ laryngeal carcinoma were include in this study,who were treated by TL (132 patients) or CRT (101 patients).These patients who had completed following time for >3 years were evaluated for function and QOL using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC),and for moods using the Beck Depression Inventory(BDI).Results: No significant difference was observed between the TL group (132 patients) and CRT group (101 patients) concerning demographic characteristics (P>0.05).In the EORTC-QLQ-C30 questionnaire,the TL group patients reported significantly better with cognitive functioning (P=0.004),and the fatigue (P=0.030) than the CRT patients.Interestingly,there was a clinically meaningful but not statistically significant difference of appetite loss (P=0.050) between the two groups,and the score was worse for the CRT group.While,according to EORTC-QLQ-C30 Head and Neck 35 questionnaire,the TL group patients reported significantly greater difficulties with speech problem (P<0.001) and the troublewith social contract (P=0.037),but the CRT group patients reported significantly greater difficulties with dry mouth (P<0.001) and the weight loss (P=0.002).No significant differences were found between the two groups with respect to the other items of this questionnaire.The 2 and 3-year survival rates were 75.4% and 61.8% for TL group,and 71.3% and 59.7% for CRT group (p=0.804),and there was no difference between them.Conclusion: Although the TL and CRT group both presented a very good QOL and similar overall survival rate,the relevant voice impairment was the main influence for the TL patients and the organ preservation appeared not necessarily equivalent to preservation of function and better QOL for CRT patients.