Determination of steroid hormones and endocrine-disrupting compounds in infant urine by high-perform

• 作 者: LiangpoLiu;JieZhang;HeqingShen;
• 机 构: Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences
• 出 处: 第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
• 发表日期: 2011年期

　　A rapid, accurate and sensitive method was developed and validated for simultaneous determination of steroid hormones and endocrine-disrupting compounds in infant urine.The target compounds were extracted by liquid-liquid extraction, derived with dansyl chloride and injected to high-performance liquid chromatography tandem mass spectrometry in positive mode.The spiked recoveries ranged from 83% to 110% with relative standard variation below 15%.The limit of detection ranged from 0.005 to 0.05 ng/ml urine.The method was applied on a preliminary investigation in 30 urine samples collected from 16 infants.Bisphenol A, triclosan, nonylphenol, and estrone were ubiquitously detected in these samples.