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The transformation of normal cells to cancer could in part be contributed to cancer stimulating signals that trigger a series of signaling events through pathways that evade the regulatory control mechanisms of DNA damage response.To explore the activated signaling pathways in cancer,we developed RepairCHIP,an integrative research platform that includes three main components: (1) RepairNET,a cellular network associated with DNA damage response; (2) RepairCHIP,an oligonucleotide microarray that contains the genes encoding the proteins of RepairNET; (3) RepairPATH,a computer algorithm that explores the potentially activated signaling pathways in cancer by integrating the knowledge of RepairNET with the measured gene expression profiles.