【摘 要】
：
Warfarin has been widely used for over 50 years as a rodent poison in pest control and also in human medicine as a prescribed anticoagulant for preventing thrombosis.The vitamin K epoxide reductase co
【机 构】
：
Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing,China;Ecology and Evo
【出 处】
：
The 5th International Conference on Rodent Biology and Manag
论文部分内容阅读
Warfarin has been widely used for over 50 years as a rodent poison in pest control and also in human medicine as a prescribed anticoagulant for preventing thrombosis.The vitamin K epoxide reductase complex subunit 1 (VKORC1) and the P450 enzymes CYP2C9 and CYP4F2 have been revealed as three main pharmacogenetic determinants of warfarin dosage in humans.Although many resistant Vkorc1 variants have been identified in rats and mice,its not clear whether the P450 gene variants are also strongly associated with warfarin resistance.Here we examine the possible orthologue genes (Vkorc1,Cyp2c11,Cyp4f1,Cyp4f4 and Cyp4f18) of human pharmacogenetic determinants for their variations and associations in 19 resistant Norway rat populations in Germany,as well as modelling panmictic virtual populations to control population stratification.We found all resistant populations carry either Y139C or S56P variant in the Vkorc1 gene.Association analysis indicated the Vkorc1 variant was strongly associated with warfarin resistance in 68%-93%local populations and all virtual populations,followed by the Cyp2c11 variant in~21%local populations and one virtual population,then the Cyp4f4 variant in 5%-7%local populations and one virtual population.Our findings indicate natural selection on Vkorc1 has led to establishment of a high proportion of resistant rats in the study area.The Cyp2c11 and Cyp4f4 variants also appear under warfarin selection but have not been established firmly in the region due to strong effect on drift.
其他文献
On farms,the emergence of protozoan parasites such as Neospora caninum and Toxoplasma gondii may have severe consequences for the health of livestock and/or humans that consume products of these anima
This study investigated the epidemiology of plague among marmots,Marmota himalayana,between 2007 to 2012 in Dege county in order to improve prevention and management plague.The main host species,marmo
Many rodent species exhibit periodic fluctuations in population abundance.This can have important consequences for processes known to be influenced by population density,such as dispersal,territoriali
It is only possible to describe,understand and predict the transmission of an infection if sufficient data are available.The incidence (the number of new infections per time unit) is a pivotal epidemi
Pest rodents damage agricultural crops,stored foods and infrastructure and are significant carriers of diseases transmitted to humans.We have assessed the efficacy of a combined rodenticide-insecticid
Arenaviruses belong to a group of rodent-borne viruses that can cause mild to severe hemorrhagic fevers.Humans mainly get infected through contact with infected rodents or their excretions,yet little
Food security is a major concern at a global level.In Southeast Asia rice is the staple crop.In 2007,rice represented 32%of agricultural output,and 29%of household calories.The challenge is to increas
The Northeast area plays an important role in grain production in China,and 25-30%of total national grain output is from this region.According to incomplete statistics,the amount of crop damaged by ro
A survey based study about farmers knowledge,attitude and practices towards rodent pest problems was conducted in four villages of Pothwar,Pakistan from September to December 2013.The aim of the study
Outbreaks of house mice (Mus domesticus) occur sporadically,and with highly variable intensity,location and extent,within cereal production regions of Australia.It is not feasible to use conventional