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前文报导的实验研究的资料表明,把“冻伤膏一号”中氢化可的松的浓度由0.5％降低至0.4％或0.3％,其对兔耳二度冻伤的疗效未见明显削弱,但若将其浓度降至0.2％,则明显地削弱它的治疗效果。可见,通过降低浓度来降低成本是有限度的,还必须摸索其它降低成本的办法。可能寻找具有类似氢化可的松药理效应的药物(尤其是中草药)来代替氢化可的松,也是降低成本和保证战时供应的重要途径。我们知道,甘草酸或甘草次酸在化学结构上与氢化可的松相似,有一定抗炎作用。临床上,曾有多人用此药代替氢化可的松治疗湿疹等皮肤病。因而用甘草酸或甘草次酸治疗一、二度冻伤的可能性是存在的。为了有对照地验证其疗效,决定观察“4％甘草酸+1％呋喃西林”霜对兔耳二度冻伤的实验疗效,并以“冻伤膏一号”作为标准对照。
The data reported in the experimental study reported earlier showed that the concentration of hydrocortisone in “Huang Zhi Gao No. 1” was reduced from 0.5% to 0.4% or 0.3%. Its effect on rabbit ear secondary frostbite was not significantly weakened, but if Reducing its concentration to 0.2% significantly impairs its therapeutic effect. It can be seen that reducing costs by reducing the concentration is limited, and other cost-reduction methods must be explored. It may be possible to search for drugs that have pharmacological effects similar to hydrocortisone (especially Chinese herbs) instead of hydrocortisone, which is also an important way to reduce costs and ensure wartime supply. We know that glycyrrhizic acid or glycyrrhetinic acid is similar in chemical structure to hydrocortisone and has a certain anti-inflammatory effect. Clinically, many people used this drug instead of hydrocortisone for the treatment of eczema and other skin diseases. Therefore, the possibility of treating first and second frostbite with glycyrrhizic acid or glycyrrhetinic acid exists. In order to verify its efficacy in a controlled manner, it was decided to observe the experimental efficacy of “4% Glycyrrhizin + 1% Nitrofurazone” cream on rabbit ear frostbite, and use “Cold No. 1” as a standard control.