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前言 近年来,对动脉压变动于80～180(甚至220)mmHg时,肾血流量(RBF)和肾小球滤过率(GFR)保持相对稳定的管-球(远曲小管-肾小球)反馈(TGF)学说的研究取得了突出的进展。经应用逆行灌流方法证明:非电解质和渗透浓度的变化不能引起TGF反应,髓袢流量增多也不是激活这一反应的真实原因,TGF反应是致密斑转运CI~-的结果,只有Br~-才能取代CI~-,而Na~+并非必需,因为有许多其它阳离子都可替代它。实验表明TGF反应在球旁装置内完成,是一种局部性的自我调节机制。
INTRODUCTION In recent years, renal artery flow (RBF) and glomerular filtration rate (GFR) have remained relatively constant in the range of 80-180 (or even 220) mmHg for arterial pressure changes (distal tubule-glomeruli The research of TGF theory has made outstanding progress. The application of retrograde perfusion method proved that the changes of electrolyte and osmotic concentration did not cause TGF reaction and the increase of medullary flow was not the real reason to activate this reaction. The TGF reaction was the result of CI - Instead of CI ~ -, Na ~ + is not necessary because there are many other cations that can replace it. Experiments show that the TGF response in the ball-side device to complete, is a local self-regulatory mechanism.