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目的探讨胃肠道间质瘤的临床病理特点及治疗方法。方法回顾性分析我院2005年7月至2010年7月期间收治的35例患者的临床资料。结果 35例患者病变分别位于胃部18例(51.4%),其中胃体15例(42.9%)、胃窦3例(8.6%);回肠16例(45.7%);小肠系膜根部1例(2.9%)。35例均进行手术治疗,其中行胃楔形切除术15例(42.9%),胃大部切除术3例(8.6%),小肠部分切除术16例(45.7%),肠系膜肿块切除加大部分小肠切除术1例(2.9%)。术后病理报告均为间质瘤;免疫组织化学染色结果:CD117阳性33例(94.3%),CD34阳性26例(74.3%)。35例术后均获随访,随访时间6个月至5年,平均25.6个月。1例术后10个月死于肿瘤复发,1例术后4个月死于短肠综合征、营养不良,余33例无肿瘤复发。结论胃肠道间质瘤确诊依赖于病理组织学检查及免疫组化染色,完整切除病灶是最有效的治疗手段。
Objective To investigate the clinicopathological characteristics and treatment of gastrointestinal stromal tumors. Methods The clinical data of 35 patients admitted to our hospital from July 2005 to July 2010 were retrospectively analyzed. Results The lesions of 35 patients were located in the stomach (18 cases, 51.4%), including 15 cases of gastric body (42.9%), 3 cases of gastric antrum (8.6%), 16 cases of ileum (45.7% 2.9%). Thirty-five cases underwent surgical resection, including 15 cases (42.9%) underwent gastric wedge resection, 3 cases underwent subtotal gastrectomy (8.6%), 16 cases (45.7%) underwent partial resection of the small intestine, Excision in 1 case (2.9%). The pathological reports were all stromal tumors. Immunohistochemical results showed that there were 33 (94.3%) positive for CD117 and 26 (74.3%) for CD34 positive. All 35 patients were followed up for 6 months to 5 years with an average of 25.6 months. One patient died of tumor recurrence 10 months after operation, one patient died of short bowel syndrome 4 months after operation, malnutrition, and the remaining 33 patients had no tumor recurrence. Conclusion The diagnosis of gastrointestinal stromal tumors depends on histopathological examination and immunohistochemical staining. Complete resection of lesions is the most effective treatment.