论文部分内容阅读
目的观察大蒜素胶囊、阿莫西林、甲硝唑、奥美拉唑四联疗法对幽门螺杆菌(Hp)阳性十二指肠溃疡的疗效。方法将Hp阳性的十二指肠溃疡患者198例随机分为两组,实验组102例,口服阿莫西林+奥美拉唑+甲硝唑+大蒜素胶囊治疗;对照组96例,口服阿莫西林+奥美拉唑+甲硝唑治疗,疗程均为7 d。7 d后两组均继续服用3周奥美拉唑。停药4周后复查胃镜、快速尿素酶试验与14C尿素呼气试验,评估Hp根除率及溃疡愈合率。结果Hp根除率两组间显著差异有统计学意义(P<0.05),溃疡愈合率两组间差异有统计学意义(P<0.05)。结论大蒜素、阿莫西林、甲硝唑、奥美拉唑四联疗法能有效根除十二指肠溃疡患者的Hp感染,治愈十二指肠溃疡。该四联方案疗效可靠,且安全,价格低廉,患者依从性好,值得临床推广应用。
Objective To observe the effect of allicin, amoxicillin, metronidazole and omeprazole quadruple therapy on Helicobacter pylori (Hp) positive duodenal ulcer. Methods A total of 198 Hp-positive duodenal ulcer patients were randomly divided into two groups. 102 cases in the experimental group were treated with oral administration of amoxicillin + omeprazole + metronidazole + allicin. In the control group, 96 cases were treated orally Moxillin + omeprazole + metronidazole treatment, treatment were 7 d. Both groups continued taking omeprazole for 3 weeks after 7 days. Four weeks after discontinuation of gastroscopy review, rapid urease test and 14C urea breath test to assess the eradication rate and ulcer healing rate. Results There was a significant difference between the two groups in the eradication rate of Hp (P <0.05). There was significant difference between the two groups in the healing rate of ulcer (P <0.05). Conclusion Allicin, amoxicillin, metronidazole and omeprazole quadruple therapy can effectively eradicate Hp infection in patients with duodenal ulcer and cure duodenal ulcer. The quadruple program efficacy and reliable, and safe, low prices, patient compliance is good, worthy of clinical application.