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选择39名临床显示有耐砜类药的门诊治疗病例。他们虽经相当长期的氨苯砜治疗但细菌指数高。对于有组织样麻风的特征或虽经充分治疗仍出现病情急性加剧者也予选入。39例中31例为瘤型,4例为界线类偏瘤型,4例为组织样麻风。方法:从细菌指数和形态指数高的活动皮疹取材制成麻风杆菌悬液,注入正常CBA鼠的足垫中,具体方法按照Job于1970年和1974年所报导者。每一标本的实验动物分4组,每组6只。第一组喂含0.01％氨苯砜(DDS)的饲料,第二组喂含0.001％DDS,第三组喂含0.0001％DDS,第四组喂无药物的正常饲料。各于6、8和10月末剖验每组中2只动物,取足垫判定麻风杆菌的繁殖情况。
Thirty-nine outpatients with clinically indicated sulfone-resistant drugs were selected for treatment. Although they are treated with dapsone for quite a long time, they have a high bacterial index. The characteristics of a tissue-like leprosy, or those who are still experiencing an acute exacerbation despite adequate treatment, are also enrolled. Among the 39 cases, 31 cases were tumor type, 4 cases were borderline off-type and 4 cases were tissue-like leprosy. METHODS: Leprosy suspensions were prepared from active rashes with high bacterial and morphological indices and injected into the foot pads of normal CBA mice as reported by Jobs in 1970 and 1974. The experimental animals of each specimen were divided into 4 groups, 6 in each group. The first group fed diets containing 0.01% dapsone (DDS), the second group fed 0.001% DDS, the third group fed 0.0001% DDS, and the fourth group fed normal diets without drug. Two animals in each group were sacrificed at the end of 6, 8 and 10 months, and footprints were taken to determine the reproduction of Leprosy.