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人体细胞的正常生长依赖于细胞周期中各种调节因子的平衡调控,任何一种调控因子发生紊乱将导致细胞异常增殖,从而诱发肿瘤[1]。细胞生长从G1→S→G2→M有着严格的周期顺序及时间。在此细胞周期中,存在着控制细胞由G1期到S期、G2期到M期转换的检查点(check point)。其中处于G1晚
The normal growth of human cells depends on the balance of various regulatory factors in the cell cycle. Any disorder of regulatory factors will lead to abnormal cell proliferation and tumor induction [1]. Cell growth from G1 → S → G2 → M has a strict cycle order and time. In this cell cycle, there is a check point that controls the transition of cells from G1 phase to S phase and G2 phase to M phase. Which is at G1 late