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目的研究老年原发性高血压患者颈动脉粥样斑块与血清C反应蛋白(CRP)的关系。方法100例老年原发性高血压患者,其中男93例,女7例,平均年龄73±7岁。应用超声多普勒对所有病例的颈动脉进行检查,检测颈动脉内膜中层厚度(IMT)及粥样斑块。用免疫学方法测定血清中CRP浓度,然后分析超声结果与CRP浓度的关系。结果随着IMT增厚,CRP浓度亦增高(P<0.05)。高血压级别越高,IMT越厚,不同级别间相比较差异有显著性(P<0.05)。粥样斑块1、2、3级CRP浓度高于粥样斑块0级(P<0.05)。结论老年原发性高血压患者血清中CRP浓度与颈动脉IMT、斑块级别呈正相关,CRP对判断动脉粥样硬化程度具有一定的意义,可作为了解动脉粥样硬化程度、指导治疗、判断预后的指标。
Objective To investigate the relationship between carotid plaque and serum C-reactive protein (CRP) in elderly patients with essential hypertension. Methods 100 elderly patients with essential hypertension, including 93 males and 7 females, with an average age of 73 ± 7 years. Carotid artery in all cases was examined with Doppler ultrasound to detect carotid intima-media thickness (IMT) and plaque. Serum CRP concentrations were measured by immunological methods and the relationship between ultrasound results and CRP concentrations was analyzed. Results With the thickening of IMT, CRP concentration also increased (P <0.05). The higher the level of hypertension, the thicker IMT, the difference between different levels was significant (P <0.05). CRP concentrations in atherosclerotic plaques 1, 2 and 3 were higher than those in atherosclerotic plaques (P <0.05). Conclusion Serum CRP levels in elderly patients with essential hypertension have a positive correlation with carotid artery IMT and plaque grade. CRP has a certain significance in judging the degree of atherosclerosis and can be used as a guide to understand the degree of atherosclerosis, guide treatment and prognosis index of.