TSE-1基因缺陷小鼠出现肺泡Ⅱ型细胞异常表型

• 作 者: 徐琳凯 董浩迪 朱婷 赵德明 杨利峰
• 机 构: 中国农业大学动物医学院,
• 出 处: 实验动物科学
• 发表日期: 2015年06期
• 关键词: 肺泡Ⅱ型上皮细胞 模型 疾病 基因敲除 Alveolar epithelial cell Ⅱ model disease gene knockout

肺泡II型上皮细胞(AT II)是肺泡表面的一类重要细胞,正常情况下不易被直接观察到。现在发现一种基因敲除小鼠(TSE-1)的肺脏内出现肺泡II型细胞增多且体积明显增大的现象。本文对这一现象结合图片进行了介绍,并总结了肺泡II型细胞的生理功能和可能与TSE-1的关系。在转基因小鼠中的该发现可使大量AT II在光镜下直接被观察到,使关于AT II的动物实验敏感性升高,为未来的肺病生理研究提供了动物模型和物质基础。

Alveolar type II epithelial cells (AT II) is a type of alveolar surface of important cells, under normal circumstances is not easy to be directly observed. It has now been found that there is an increase in alveolar type II cells in the lungs of a knockout mouse (TSE-1) and a markedly increased volume. This article describes the phenomenon combined with pictures and summarizes the physiological function of alveolar type II cells and possible relationship with TSE-1. This finding in transgenic mice allows for the direct observation of a large number of AT II under light microscopy, raising the sensitivity of animal experiments on AT II to provide an animal model and material basis for future lung pathophysiology.