论文部分内容阅读
目的调查江苏地区孕妇人群分娩时及产后7个月~12个月母婴戊型肝炎病毒(HEV)感染状况,并观察母源性抗-HEV Ig G抗体的胎盘通过以及在新生儿体内的衰减情况。方法纳入江苏省6个县市住院分娩的552例孕妇,采分娩时母血及脐血,并于产后平均为9.8个月(7个月~12个月)对母婴进行随访。采用ELISA法初筛血清抗-HEV Ig G和Ig M抗体,初筛阳性血清进一步采用Western blotting确认。结果所有孕妇抗-HEV Ig M均阴性,60例(10.9%)抗-HEV Ig G阳性。分娩时抗-HEV Ig G阳性的36例孕妇产后随访时仍阳性;分娩时抗-HEV Ig G阴性的212例孕妇产后随访时抗-HEV Ig M均阴性,3例(1.4%)抗-HEV Ig G转阳。60例抗-HEV Ig G阳性孕妇的新生儿脐血抗-HEV Ig G阳性57例(95.0%),33例产后随访均转为阴性。随访215例脐血抗-HEV Ig G阴性新生儿,抗-HEV Ig G及Ig M均阴性。结论江苏省孕妇人群抗-HEV Ig G血清流行率为10.9%,孕期新发感染极低。母源性抗-HEV Ig G抗体可高效通过胎盘,在10月龄前转阴。婴儿几乎不发生HEV感染。
Objective To investigate the status of hepatitis E virus (HEV) infection among pregnant women in Jiangsu province during childbirth and from 7 months to 12 months after delivery and to observe the placenta passage of maternal anti-HEV Ig G antibody and its attenuation in neonates Happening. Methods A total of 552 pregnant women in hospital delivery in 6 counties of Jiangsu Province were enrolled in this study. Maternal and umbilical blood were collected during delivery. The average postpartum period was 9.8 months (range, 7 months to 12 months). Serum anti-HEV Ig G and Ig M antibodies were preliminarily screened by ELISA, and the primary sera were further confirmed by Western blotting. Results All pregnant women were negative for anti-HEV Ig M, and 60 (10.9%) were positive for anti-HEV Ig G. 36 pregnant women with positive anti-HEV Ig G during childbirth were still positive at postnatal follow-up; 212 pregnant women with negative anti-HEV Ig G during childbirth were all negative for anti-HEV Ig M postpartum and 3 (1.4%) anti-HEV Ig G turn the sun. Fifty-six (95.0%) neonates with anti-HEV IgG positive pregnant women had cord blood anti-HEV Ig G positive, and 33 of them were negative after they were followed up. 215 cases of cord blood anti-HEV Ig G-negative neonates were followed up, and anti-HEV Ig G and Ig M were negative. Conclusion The prevalence of anti-HEV Ig G in pregnant women in Jiangsu province is 10.9%, and the infection rate during pregnancy is extremely low. Maternal anti-HEV Ig G antibodies pass efficiently through the placenta and are negative before 10 months of age. Infants rarely develop HEV infection.