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作者对43例结肠直肠癌伴盆腔复发采用下列方案治疗:(1)术前给盆腔外束放疗(EBRT)5周以及静脉注射5-FU和/或顺铂;放疗量为45Gy,分25次照射;5FU量为250～300mg/m~2,顺铂量为4mg/m~2,半数病人仅用5-FU。(2)手术切除复发灶。21例并在术中给放疗20～40Gy。(3)术后辅佐化疗,14例采用5-FU化疗。全组中,22例男性,21例女性,平均年龄56.2岁(32～79岁)。34例为直肠癌,9例为乙状结肠癌。 结果 (一)切除率和切缘 95％病例原保留了肛括约肌。化疗放疗后,3例病灶仍进展,列为不能手术。在余下的40例中,7例病灶不能切除(18％),
The authors treated 43 cases of colorectal cancer with pelvic recurrence using the following regimens: (1) preoperative pelvic external beam radiotherapy (EBRT) for 5 weeks and intravenous injection of 5-FU and/or cisplatin; radiation dose of 45Gy, 25 times Irradiation; 5FU amount was 250-300mg/m~2, cisplatin amount was 4mg/m~2, half of patients only used 5-FU. (2) surgical resection of recurrent foci. In 21 patients, 20 to 40 Gy of radiotherapy was given during surgery. (3) Postoperative adjuvant chemotherapy, 14 patients received 5-FU chemotherapy. In the entire group, there were 22 males and 21 females with an average age of 56.2 years (32 to 79 years). Thirty-four cases were rectal cancer and 9 cases were sigmoid colon cancer. Results (a) The resection rate and 95% of margins retained the anal sphincter. After radiotherapy for chemotherapy, 3 lesions still progressed and were classified as inoperable. Of the remaining 40 cases, 7 lesions could not be removed (18%).